Proof of concept demonstration of optimal composite MRI endpoints for clinical trials

INTRODUCTION: Atrophy measures derived from structural MRI are promising outcome measures for early phase clinical trials, especially for rare diseases such as primary progressive aphasia (PPA), where the small available subject pool limits our ability to perform meaningfully powered trials with tra...

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Detalles Bibliográficos
Autores principales: Edland, Steven D., Ard, M. Colin, Sridhar, Jaiashre, Cobia, Derin, Martersteck, Adam, Mesulam, M.-Marsel, Rogalski, Emily J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363955/
https://www.ncbi.nlm.nih.gov/pubmed/28345017
http://dx.doi.org/10.1016/j.trci.2016.05.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363955/
https://www.ncbi.nlm.nih.gov/pubmed/28345017
http://dx.doi.org/10.1016/j.trci.2016.05.002

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