Autism gene Ube3a and seizures impair sociability by repressing VTA Cbln1

Maternally inherited 15q11-13 chromosomal triplications cause a frequent and highly penetrant autism linked to increased gene dosages of UBE3A, which both possesses ubiquitin-ligase and transcriptional co-regulatory functions. Here, using in vivo mouse genetics, we show that increasing UBE3A in the...

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Detalles Bibliográficos
Autores principales: Krishnan, Vaishnav, Stoppel, David C., Nong, Yi, Johnson, Mark A., Nadler, Monica J.S., Ozkaynak, Ekim, Teng, Brian L., Nagakura, Ikue, Mohammad, Fahim, Silva, Michael A., Peterson, Sally, Cruz, Tristan J., Kasper, Ekkehard M., Arnaout, Ramy, Anderson, Matthew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364052/
https://www.ncbi.nlm.nih.gov/pubmed/28297715
http://dx.doi.org/10.1038/nature21678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364052/
https://www.ncbi.nlm.nih.gov/pubmed/28297715
http://dx.doi.org/10.1038/nature21678

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