Cargando…

Autism gene Ube3a and seizures impair sociability by repressing VTA Cbln1

Maternally inherited 15q11-13 chromosomal triplications cause a frequent and highly penetrant autism linked to increased gene dosages of UBE3A, which both possesses ubiquitin-ligase and transcriptional co-regulatory functions. Here, using in vivo mouse genetics, we show that increasing UBE3A in the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Krishnan, Vaishnav, Stoppel, David C., Nong, Yi, Johnson, Mark A., Nadler, Monica J.S., Ozkaynak, Ekim, Teng, Brian L., Nagakura, Ikue, Mohammad, Fahim, Silva, Michael A., Peterson, Sally, Cruz, Tristan J., Kasper, Ekkehard M., Arnaout, Ramy, Anderson, Matthew P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364052/ https://www.ncbi.nlm.nih.gov/pubmed/28297715 http://dx.doi.org/10.1038/nature21678

Ejemplares similares

UBE3A and transsynaptic complex NRXN1-CBLN1-GluD1 in a hypothalamic VMHvl-arcuate feedback circuit regulates aggression
por: Nong, Yi, et al.
Publicado: (2023)

Improvement of cerebellar ataxic gait by injecting Cbln1 into the cerebellum of cbln1-null mice
por: Takeuchi, Eri, et al.
Publicado: (2018)

Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction
por: Bariselli, Sebastiano, et al.
Publicado: (2018)

Cbln1 regulates axon growth and guidance in multiple neural regions
por: Han, Peng, et al.
Publicado: (2022)

Sociability
Publicado: (1876)

CBLN2 rs2217560 was Associated with Pulmonary Arterial Hypertension in Systemic Lupus Erythematosus
por: Huang, Can, et al.
Publicado: (2018)

College Sociability
Publicado: (1880)

Hominoid SVA-lncRNA AK057321 targets human-specific SVA retrotransposons in SCN8A and CDK5RAP2 to initiate neuronal maturation
por: Nadler, Monica J. S., et al.
Publicado: (2023)

Cbln1 Directs Axon Targeting by Corticospinal Neurons Specifically toward Thoraco-Lumbar Spinal Cord
por: Song, Janet H.T., et al.
Publicado: (2023)

Designing sociable robots /
por: Breazeal, Cynthia L.
Publicado: (2002)

Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation
por: Berrios, Janet, et al.
Publicado: (2016)

Reevaluation of the role of parallel fiber synapses in delay eyeblink conditioning in mice using Cbln1 as a tool
por: Emi, Kyoichi, et al.
Publicado: (2013)

The relationship between sociability and productivity
por: Karimi, Saeed, et al.
Publicado: (2014)

Deregulation of UBE2C-mediated autophagy repression aggravates NSCLC progression
por: Guo, Jiwei, et al.
Publicado: (2018)

Un Dios sociable : introducción a la sociología trascendental /
por: Wilber, Ken
Publicado: (1988)

VtaA8 and VtaA9 from Haemophilus parasuis delay phagocytosis by alveolar macrophages
por: Costa-Hurtado, Mar, et al.
Publicado: (2012)

The Lateral Preoptic Area and Its Projection to the VTA Regulate VTA Activity and Drive Complex Reward Behaviors
por: Gordon-Fennell, Adam, et al.
Publicado: (2020)

Family-Based Cohort Association Study of PRKCB1, CBLN1 and KCNMB4 Gene Polymorphisms and Autism in Polish Population
por: Iwanicki, Tomasz, et al.
Publicado: (2021)

Sociable skill with the CERN Darts Club
Publicado: (1996)

Loneliness, depression and sociability in old age
por: Singh, Archana, et al.
Publicado: (2009)

Genetic underpinnings of sociability in the general population
por: Bralten, Janita, et al.
Publicado: (2021)

Editorial: Emotional Function of Sociability in Fish
por: Soares, Marta C., et al.
Publicado: (2022)

A siRNA screening of UBE2 family demonstrated that UBE2R1 had a high repressive effect on HIV Tat protein
por: Xu, Muyu, et al.
Publicado: (2022)

Language and sociability: insights from Williams syndrome
por: Fishman, Inna, et al.
Publicado: (2011)

Using activity and sociability to characterize collective motion
por: Sumpter, David J. T., et al.
Publicado: (2018)

Sociability between invasive guppies and native topminnows
por: Camacho-Cervantes, Morelia, et al.
Publicado: (2018)

A Global Reassessment of Solitary-Sociable Dolphins
por: Nunny, Laetitia, et al.
Publicado: (2019)

No child is an island: sociability in times of social distancing
por: Maria, Melchior
Publicado: (2020)

Advantages and Limitations of Anticipating Laboratory Test Results from Regression- and Tree-Based Rules Derived from Electronic Health-Record Data
por: Mohammad, Fahim, et al.
Publicado: (2014)

The Role of Dopaminergic VTA Neurons in General Anesthesia
por: Zhou, Xuelong, et al.
Publicado: (2015)

Periaqueductal efferents to dopamine and GABA neurons of the VTA
por: Ntamati, Niels R., et al.
Publicado: (2018)

VTA GABA Neurons at the Interface of Stress and Reward
por: Bouarab, Chloé, et al.
Publicado: (2019)

Identification and Characterization of BmVta1, a Bombyx mori (Lepidoptera: Bombycidae) Homologue for Vta1 That is Up-Regulated in Development
por: Xia, Hengchuan, et al.
Publicado: (2017)

Effect of diazepam on sociability of rats submitted to neonatal seizures
por: Leite, Ingrid Stanize, et al.
Publicado: (2016)

Corrigendum: A Global Reassessment of Solitary-Sociable Dolphins
por: Nunny, Laetitia, et al.
Publicado: (2019)

Beat Perception and Sociability: Evidence from Williams Syndrome
por: Lense, Miriam D., et al.
Publicado: (2016)

The Sociability Argument for the Burqa Ban: A Qualified Defence
por: de Vries, Bouke
Publicado: (2021)

Increased Sociability in Mice Lacking Intergenic Dlx Enhancers
por: Fazel Darbandi, Siavash, et al.
Publicado: (2021)

The Association Between Sociability and COVID-19 Pandemic Stress
por: Luo, Peihao, et al.
Publicado: (2022)

Bugs R Us: Restoring sociability with microbiota in autism
por: Bellone, Camilla, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_1sumtmua4ongkp6bk36ff7g6pr