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Topical dura mater application of CFA induces enhanced expression of c-fos and glutamate in rat trigeminal nucleus caudalis: attenuated by KYNA derivate (SZR72)

BACKGROUND: Migraine is a debilitating neurological disorder where trigeminovascular activation plays a key role. We have previously reported that local application of Complete Freund’s Adjuvant (CFA) onto the dura mater caused activation in rat trigeminal ganglion (TG) which was abolished by a syst...

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Detalles Bibliográficos
Autores principales: Lukács, M., Warfvinge, K., Tajti, J., Fülöp, F., Toldi, J., Vécsei, L., Edvinsson, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364126/
https://www.ncbi.nlm.nih.gov/pubmed/28337634
http://dx.doi.org/10.1186/s10194-017-0746-x