Early-Onset Network Hyperexcitability in Presymptomatic Alzheimer’s Disease Transgenic Mice Is Suppressed by Passive Immunization with Anti-Human APP/Aβ Antibody and by mGluR5 Blockade

Cortical and hippocampal network hyperexcitability appears to be an early event in Alzheimer’s disease (AD) pathogenesis, and may contribute to memory impairment. It remains unclear if network hyperexcitability precedes memory impairment in mouse models of AD and what are the underlying cellular mec...

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Detalles Bibliográficos
Autores principales: Kazim, Syed F., Chuang, Shih-Chieh, Zhao, Wangfa, Wong, Robert K. S., Bianchi, Riccardo, Iqbal, Khalid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364175/
https://www.ncbi.nlm.nih.gov/pubmed/28392767
http://dx.doi.org/10.3389/fnagi.2017.00071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364175/
https://www.ncbi.nlm.nih.gov/pubmed/28392767
http://dx.doi.org/10.3389/fnagi.2017.00071

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