Cargando…

Early-Onset Network Hyperexcitability in Presymptomatic Alzheimer’s Disease Transgenic Mice Is Suppressed by Passive Immunization with Anti-Human APP/Aβ Antibody and by mGluR5 Blockade

Cortical and hippocampal network hyperexcitability appears to be an early event in Alzheimer’s disease (AD) pathogenesis, and may contribute to memory impairment. It remains unclear if network hyperexcitability precedes memory impairment in mouse models of AD and what are the underlying cellular mec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kazim, Syed F., Chuang, Shih-Chieh, Zhao, Wangfa, Wong, Robert K. S., Bianchi, Riccardo, Iqbal, Khalid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364175/ https://www.ncbi.nlm.nih.gov/pubmed/28392767 http://dx.doi.org/10.3389/fnagi.2017.00071

Ejemplares similares

APP Causes Hyperexcitability in Fragile X Mice
por: Westmark, Cara J., et al.
Publicado: (2016)

Group I mGluRs in Therapy and Diagnosis of Parkinson’s Disease: Focus on mGluR5 Subtype
por: Azam, Shofiul, et al.
Publicado: (2022)

Metabotropic glutamate receptors (mGluRs) in epileptogenesis: an update on abnormal mGluRs signaling and its therapeutic implications
por: Huang, Leyi, et al.
Publicado: (2023)

mGluR5, CB1 and neuroprotection
por: Carvalho, Toniana G., et al.
Publicado: (2016)

The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency
por: Kammermeier, Paul J
Publicado: (2012)

The Changes in mGluR2 and mGluR7 Expression in Rat Medial Vestibular Nucleus and Flocculus Following Unilateral Labyrinthectomy
por: Zhou, Wen, et al.
Publicado: (2013)

Pretreatment with mGluR2 or mGluR3 Agonists Reduces Apoptosis Induced by Hypoxia-Ischemia in Neonatal Rat Brains
por: Bratek - Gerej, Ewelina, et al.
Publicado: (2021)

mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia
por: Wang, Hoau-Yan, et al.
Publicado: (2018)

mGluR5 Is Substitutable for mGluR1 in Cerebellar Purkinje Cells for Motor Coordination, Developmental Synapse Elimination, and Motor Learning
por: Harbers, Maria, et al.
Publicado: (2022)

Investigating the role of mGluR2 versus mGluR3 in antipsychotic-like effects, sleep-wake architecture and network oscillatory activity using novel Han Wistar rats lacking mGluR2 expression
por: Wood, Christian M., et al.
Publicado: (2018)

mGluR-Dependent Synaptic Plasticity in Drug-Seeking
por: Bellone, Camilla, et al.
Publicado: (2012)

PET imaging of mGluR5 in Alzheimer’s disease
por: Mecca, Adam P., et al.
Publicado: (2020)

Extinction-Dependent Alterations in Corticostriatal mGluR2/3 and mGluR7 Receptors following Chronic Methamphetamine Self-Administration in Rats
por: Schwendt, Marek, et al.
Publicado: (2012)

Opposite Effects of mGluR1a and mGluR5 Activation on Nucleus Accumbens Medium Spiny Neuron Dendritic Spine Density
por: Gross, Kellie S., et al.
Publicado: (2016)

mGluR2/3 blockade produces rapid and long-lasting reversal of anhedonia caused by chronic stress exposure
por: Dwyer, Jason M, et al.
Publicado: (2013)

Transgenerational deep sequencing revealed hypermethylation of hippocampal mGluR1 gene with altered mRNA expression of mGluR5 and mGluR3 associated with behavioral changes in Sprague Dawley rats with history of prolonged febrile seizure
por: Alese, Oluwole Ojo, et al.
Publicado: (2019)

Target validation: Weak selectivity of LY341495 for mGluR2 over mGluR4 makes glutamate a less selective agonist
por: McCullock, Tyler W., et al.
Publicado: (2019)

Alterations in mGluR5 Expression and Signaling in Lewy Body Disease and in Transgenic Models of Alpha-Synucleinopathy – Implications for Excitotoxicity
por: Price, Diana L., et al.
Publicado: (2010)

Two routes to autism phenotypes via mGluR5
Publicado: (2012)

Translational Concepts of mGluR5 in Synaptic Diseases of the Brain
por: Piers, Thomas M., et al.
Publicado: (2012)

Therapeutic potential of mGluR5 targeting in Alzheimer's disease
por: Kumar, Anil, et al.
Publicado: (2015)

Neuromodulation by mGluRs in Sound Localization Circuits in the Auditory Brainstem
por: Goel, Nupur, et al.
Publicado: (2020)

Reduced mGluR5 Activity Modulates Mitochondrial Function
por: Gonzalez-Lozano, Miguel A., et al.
Publicado: (2021)

Selective Recruitment of Presynaptic and Postsynaptic Forms of mGluR-LTD
por: Sanderson, Thomas M., et al.
Publicado: (2022)

Role for Astrocytes in mGluR-Dependent LTD in the Neocortex and Hippocampus
por: Lalo, Ulyana, et al.
Publicado: (2022)

mGluR-dependent plasticity in rodent models of Alzheimer’s disease
por: Valdivia, Gonzalo, et al.
Publicado: (2023)

mGluR5 in amygdala modulates fear memory generalization
por: Xuan, Shou-Min, et al.
Publicado: (2023)

Loss of retinoid X receptor gamma subunit impairs group 1 mGluR mediated electrophysiological responses and group 1 mGluR dependent behaviors
por: Upreti, Chirag, et al.
Publicado: (2021)

Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro
por: Neyman, Sergey, et al.
Publicado: (2008)

Disrupted mGluR5-Homer scaffolds mediate abnormal mGluR5 signaling, circuit function and behavior in a mouse model of Fragile X Syndrome
por: Ronesi, Jennifer A., et al.
Publicado: (2012)

Nanoscopic spine localization of Norbin, an mGluR5 accessory protein
por: Westin, Linda, et al.
Publicado: (2014)

Coordination between Translation and Degradation Regulates Inducibility of mGluR-LTD
por: Klein, Matthew E., et al.
Publicado: (2015)

Orchestrated activation of mGluR5 and CB(1) promotes neuroprotection
por: Batista, Edleusa M. L., et al.
Publicado: (2016)

Conformational pathway provides unique sensitivity to a synaptic mGluR
por: Habrian, Chris H., et al.
Publicado: (2019)

Are mGluR2/3 Inhibitors Potential Compounds for Novel Antidepressants?
por: Jiang, Yajie, et al.
Publicado: (2022)

Anti-mGluR1 encephalitis: Case illustration and systematic review
por: Khojah, Osama, et al.
Publicado: (2023)

Selective Blockade of the Metabotropic Glutamate Receptor mGluR5 Protects Mouse Livers in In Vitro and Ex Vivo Models of Ischemia Reperfusion Injury
por: Ferrigno, Andrea, et al.
Publicado: (2018)

Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington’s pathology in zQ175 mice
por: Abd-Elrahman, Khaled S., et al.
Publicado: (2019)

Glu-mGluR2/3-ERK Signaling Regulates Apoptosis of Hippocampal Neurons in Diabetic-Depression Model Rats
por: Liu, Zhuo, et al.
Publicado: (2019)

FMRP Mediates mGluR(5)-Dependent Translation of Amyloid Precursor Protein
por: Westmark, Cara J, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_sa51dnbvpch4btvhhto739f414