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Adverse outcome pathway development from protein alkylation to liver fibrosis

In modern toxicology, substantial efforts are undertaken to develop alternative solutions for in vivo toxicity testing. The adverse outcome pathway (AOP) concept could facilitate knowledge-based safety assessment of chemicals that does not rely exclusively on in vivo toxicity testing. The constructi...

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Detalles Bibliográficos
Autores principales: Horvat, Tomislav, Landesmann, Brigitte, Lostia, Alfonso, Vinken, Mathieu, Munn, Sharon, Whelan, Maurice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364266/
https://www.ncbi.nlm.nih.gov/pubmed/27542122
http://dx.doi.org/10.1007/s00204-016-1814-8