Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics

Liquid-liquid phase separation (LLPS) of RNA-binding proteins plays an important role in the formation of multiple membrane-less organelles involved in RNA metabolism, including stress granules. Defects in stress granule homeostasis constitute a cornerstone of ALS/FTLD pathogenesis. Polar residues (...

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Detalles Bibliográficos
Autores principales: Boeynaems, Steven, Bogaert, Elke, Kovacs, Denes, Konijnenberg, Albert, Timmerman, Evy, Volkov, Alex, Guharoy, Mainak, De Decker, Mathias, Jaspers, Tom, Ryan, Veronica H., Janke, Abigail M., Baatsen, Pieter, Vercruysse, Thomas, Kolaitis, Regina-Maria, Daelemans, Dirk, Taylor, J. Paul, Kedersha, Nancy, Anderson, Paul, Impens, Francis, Sobott, Frank, Schymkowitz, Joost, Rousseau, Frederic, Fawzi, Nicolas L., Robberecht, Wim, Van Damme, Philip, Tompa, Peter, Van Den Bosch, Ludo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364369/
https://www.ncbi.nlm.nih.gov/pubmed/28306503
http://dx.doi.org/10.1016/j.molcel.2017.02.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364369/
https://www.ncbi.nlm.nih.gov/pubmed/28306503
http://dx.doi.org/10.1016/j.molcel.2017.02.013

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