DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression

Following DNA damage caused by exogenous sources, such as ionizing radiation, the tumour suppressor p53 mediates cell cycle arrest via expression of the CDK inhibitor, p21. However, the role of p21 in maintaining genomic stability in the absence of exogenous DNA-damaging agents is unclear. Here, usi...

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Detalles Bibliográficos
Autores principales: Barr, Alexis R., Cooper, Samuel, Heldt, Frank S., Butera, Francesca, Stoy, Henriette, Mansfeld, Jörg, Novák, Béla, Bakal, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364389/
https://www.ncbi.nlm.nih.gov/pubmed/28317845
http://dx.doi.org/10.1038/ncomms14728

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364389/
https://www.ncbi.nlm.nih.gov/pubmed/28317845
http://dx.doi.org/10.1038/ncomms14728

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