Cargando…
STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling
Type I interferons (IFNs) are multifunctional cytokines that regulate immune responses and cellular functions but also can have detrimental effects on human health. A tight regulatory network therefore controls IFN signaling, which in turn interferes with medical interventions. The JAK-STAT signalin...
Autores principales: | Arimoto, Kei-ichiro, Löchte, Sara, Stoner, Samuel A., Burkart, Christoph, Zhang, Yue, Miyauchi, Sayuri, Wilmes, Stephan, Fan, Jun-Bao, Heinisch, Jürgen J., Li, Zhi, Yan, Ming, Pellegrini, Sandra, Colland, Frédéric, Piehler, Jacob, Zhang, Dong-Er |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365074/ https://www.ncbi.nlm.nih.gov/pubmed/28165510 http://dx.doi.org/10.1038/nsmb.3378 |
Ejemplares similares
-
Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis
por: Arimoto, Kei-ichiro, et al.
Publicado: (2023) -
Usp18 deficient mammary epithelial cells create an antitumour environment driven by hypersensitivity to IFN-λ and elevated secretion of Cxcl10
por: Burkart, Christoph, et al.
Publicado: (2013) -
USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response
por: François-Newton, Véronique, et al.
Publicado: (2011) -
Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex
por: Chmiest, Daniela, et al.
Publicado: (2016) -
Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus
por: Ren, Ying, et al.
Publicado: (2016)