Population genetic analysis of the DARC locus (Duffy) reveals adaptation from standing variation associated with malaria resistance in humans

The human DARC (Duffy antigen receptor for chemokines) gene encodes a membrane-bound chemokine receptor crucial for the infection of red blood cells by Plasmodium vivax, a major causative agent of malaria. Of the three major allelic classes segregating in human populations, the FY*O allele has been...

Descripción completa

Detalles Bibliográficos
Autores principales: McManus, Kimberly F., Taravella, Angela M., Henn, Brenna M., Bustamante, Carlos D., Sikora, Martin, Cornejo, Omar E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365118/
https://www.ncbi.nlm.nih.gov/pubmed/28282382
http://dx.doi.org/10.1371/journal.pgen.1006560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365118/
https://www.ncbi.nlm.nih.gov/pubmed/28282382
http://dx.doi.org/10.1371/journal.pgen.1006560

Ejemplares similares