Long-term treatment with odanacatib maintains normal trabecular biomechanical properties in ovariectomized adult monkeys as demonstrated by micro-CT-based finite element analysis

The cathepsin K inhibitor odanacatib (ODN) is a potent and reversible inhibitor of osteoclastic resorption activity. This drug is currently under development for the treatment of postmenopausal osteoporosis. Previously, we described data on the treatment efficacy of ODN in a preclinical estrogen-def...

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Detalles Bibliográficos
Autores principales: Cabal, Antonio, Williams, Donald S., Jayakar, Richa Y., Zhang, Jingru, Sardesai, Swanand, Duong, Le T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365313/
https://www.ncbi.nlm.nih.gov/pubmed/28377978
http://dx.doi.org/10.1016/j.bonr.2017.01.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365313/
https://www.ncbi.nlm.nih.gov/pubmed/28377978
http://dx.doi.org/10.1016/j.bonr.2017.01.001

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