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Distinct contributions of the thin and thick filaments to length-dependent activation in heart muscle

The Frank-Starling relation is a fundamental auto-regulatory property of the heart that ensures the volume of blood ejected in each heartbeat is matched to the extent of venous filling. At the cellular level, heart muscle cells generate higher force when stretched, but despite intense efforts the un...

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Detalles Bibliográficos
Autores principales: Zhang, Xuemeng, Kampourakis, Thomas, Yan, Ziqian, Sevrieva, Ivanka, Irving, Malcolm, Sun, Yin-Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365314/
https://www.ncbi.nlm.nih.gov/pubmed/28229860
http://dx.doi.org/10.7554/eLife.24081