Preclinical Pharmacokinetics and Pharmacodynamic Target of SCY-078, a First-in-Class Orally Active Antifungal Glucan Synthesis Inhibitor, in Murine Models of Disseminated Candidiasis

SCY-078 (MK-3118) is a novel, semisynthetic derivative of enfumafungin and represents the first compound of the triterpene class of antifungals. SCY-078 exhibits potent inhibition of β-(1,3)-d-glucan synthesis, an essential cell wall component of many pathogenic fungi, including Candida spp. and Asp...

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Detalles Bibliográficos
Autores principales: Wring, Stephen A., Randolph, Ryan, Park, SeongHee, Abruzzo, George, Chen, Qing, Flattery, Amy, Garrett, Graig, Peel, Michael, Outcalt, Russell, Powell, Kendall, Trucksis, Michelle, Angulo, David, Borroto-Esoda, Katyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365645/
https://www.ncbi.nlm.nih.gov/pubmed/28137806
http://dx.doi.org/10.1128/AAC.02068-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365645/
https://www.ncbi.nlm.nih.gov/pubmed/28137806
http://dx.doi.org/10.1128/AAC.02068-16

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