Tau Pathology Promotes the Reorganization of the Extracellular Matrix and Inhibits the Formation of Perineuronal Nets by Regulating the Expression and the Distribution of Hyaluronic Acid Synthases

Hyaluronic acid (HA) is the backbone of the extracellular matrix (ECM) and provides biochemical and physical support to aggrecan-based perineuronal nets (PNNs), which are associated with the selective vulnerability of neurons in Alzheimer’s disease (AD). Here, we showed that HA synthases (HASs), inc...

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Detalles Bibliográficos
Autores principales: Li, Yin, Li, Ze-Xu, Jin, Tan, Wang, Zhan-You, Zhao, Pu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366250/
https://www.ncbi.nlm.nih.gov/pubmed/28234253
http://dx.doi.org/10.3233/JAD-160804

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366250/
https://www.ncbi.nlm.nih.gov/pubmed/28234253
http://dx.doi.org/10.3233/JAD-160804

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