Enhancing Drug Efficacy and Therapeutic Index through Cheminformatics-Based Selection of Small Molecule Binary Weapons That Improve Transporter-Mediated Targeting: A Cytotoxicity System Based on Gemcitabine

The transport of drug molecules is mainly determined by the distribution of influx and efflux transporters for which they are substrates. To enable tissue targeting, we sought to develop the idea that we might affect the transporter-mediated disposition of small-molecule drugs via the addition of a...

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Detalles Bibliográficos
Autores principales: Grixti, Justine M., O'Hagan, Steve, Day, Philip J., Kell, Douglas B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366350/
https://www.ncbi.nlm.nih.gov/pubmed/28396636
http://dx.doi.org/10.3389/fphar.2017.00155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366350/
https://www.ncbi.nlm.nih.gov/pubmed/28396636
http://dx.doi.org/10.3389/fphar.2017.00155

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