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Spontaneously Hypertensive Rats (SHR) Are Resistant to a Reserpine-Induced Progressive Model of Parkinson’s Disease: Differences in Motor Behavior, Tyrosine Hydroxylase and α-Synuclein Expression

Reserpine is an irreversible inhibitor of vesicular monoamine transporter-2 (VMAT2) used to study Parkinson’s disease (PD) and screening for antiparkinsonian treatments in rodents. Recently, the repeated treatment with a low-dose of reserpine was proposed as a progressive model of PD. Rats under thi...

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Detalles Bibliográficos
Autores principales: Leão, Anderson H. F. F., Meurer, Ywlliane S. R., da Silva, Anatildes F., Medeiros, André M., Campêlo, Clarissa L. C., Abílio, Vanessa C., Engelberth, Rovena C. G. K., Cavalcante, Jeferson S., Izídio, Geison S., Ribeiro, Alessandra M., Silva, Regina H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366354/
https://www.ncbi.nlm.nih.gov/pubmed/28396635
http://dx.doi.org/10.3389/fnagi.2017.00078