Detecting truly clonal alterations from multi-region profiling of tumours

Modern cancer therapies aim at targeting tumour-specific alterations, such as mutations or neo-antigens, and maximal treatment efficacy requires that targeted alterations are present in all tumour cells. Currently, treatment decisions are based on one or a few samples per tumour, creating uncertaint...

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Detalles Bibliográficos
Autores principales: Werner, Benjamin, Traulsen, Arne, Sottoriva, Andrea, Dingli, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366809/
https://www.ncbi.nlm.nih.gov/pubmed/28344344
http://dx.doi.org/10.1038/srep44991

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366809/
https://www.ncbi.nlm.nih.gov/pubmed/28344344
http://dx.doi.org/10.1038/srep44991

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