Cargando…

FUSION-Guided Hypothesis Development Leads to the Identification of N(6),N(6)-Dimethyladenosine, a Marine-Derived AKT Pathway Inhibitor

Chemicals found in nature have evolved over geological time scales to productively interact with biological molecules, and thus represent an effective resource for pharmaceutical development. Marine-derived bacteria are rich sources of chemically diverse, bioactive secondary metabolites, but harness...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vaden, Rachel M., Oswald, Nathaniel W., Potts, Malia B., MacMillan, John B., White, Michael A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367032/ https://www.ncbi.nlm.nih.gov/pubmed/28294973 http://dx.doi.org/10.3390/md15030075

Ejemplares similares

Formation and removal of 1,N(6)-dimethyladenosine in mammalian transfer RNA
por: You, Xue-Jiao, et al.
Publicado: (2022)

PCIF1, the only methyltransferase of N6,2-O-dimethyladenosine
por: Wu, Yuting, et al.
Publicado: (2023)

Dynamic regulation of N(6),2′-O-dimethyladenosine (m(6)Am) in obesity
por: Ben-Haim, Moshe Shay, et al.
Publicado: (2021)

Identification of N(6),N(6)-Dimethyladenosine in Transfer RNA from Mycobacterium bovis Bacille Calmette-Guérin
por: Chan, Clement T.Y., et al.
Publicado: (2011)

Viral and Cellular N(6)-Methyladenosine (m(6)A) and N(6), 2′-O-Dimethyladenosine (m(6)Am) Epitranscriptomes in KSHV Life Cycle
por: Tan, Brandon, et al.
Publicado: (2017)

Synthesis of aminoacylated N(6),N(6)-dimethyladenosine solid support for efficient access to hydrolysis-resistant 3′-charged tRNA mimics
por: Neuner, Sandro, et al.
Publicado: (2014)

EMDL_m6Am: identifying N6,2′-O-dimethyladenosine sites based on stacking ensemble deep learning
por: Jia, Jianhua, et al.
Publicado: (2023)

Antiviral Potential of Small Molecules Cordycepin, Thymoquinone, and N6, N6-Dimethyladenosine Targeting SARS-CoV-2 Entry Protein ADAM17
por: He, Jiayue, et al.
Publicado: (2022)

DLm6Am: A Deep-Learning-Based Tool for Identifying N6,2′-O-Dimethyladenosine Sites in RNA Sequences
por: Luo, Zhengtao, et al.
Publicado: (2022)

Quantitative Analysis of Methylated Adenosine Modifications Revealed Increased Levels of N(6)-Methyladenosine (m(6)A) and N(6),2′-O-Dimethyladenosine (m(6)Am) in Serum From Colorectal Cancer and Gastric Cancer Patients
por: Hu, Yiqiu, et al.
Publicado: (2021)

A mitochondrial rRNA dimethyladenosine methyltransferase in Arabidopsis
por: Richter, Uwe, et al.
Publicado: (2010)

Dimethyladenosine Transferase 1 Homolog Promotes Human Gastric Carcinoma Cell Proliferation and Inhibits Apoptosis via the AKT Pathway
por: Liu, Guang-yi, et al.
Publicado: (2023)

PCIF1-mediated deposition of 5′-cap N(6),2′-O-dimethyladenosine in ACE2 and TMPRSS2 mRNA regulates susceptibility to SARS-CoV-2 infection
por: Wang, Lingling, et al.
Publicado: (2023)

1,3-Oxazin-6-one Derivatives and Bohemamine-Type Pyrrolizidine Alkaloids from a Marine-Derived Streptomyces spinoverrucosus
por: Fu, Peng, et al.
Publicado: (2015)

Elevation of Nitric Oxide Synthase Activity by Dimethyladenosine from Silkworm Pupae in Aged Rats
por: Ahn, Mi Young, et al.
Publicado: (2008)

N (4),N (6)-Dimethyl-N (4),N (6)-diphenylpyrimidine-4,5,6-triamine
por: Shi, Fuqiang, et al.
Publicado: (2011)

{N,N-Bis[2-(trimethylsilylamino)ethyl]-N′-(trimethylsilyl)ethane-1,2-diaminato(3–)-κ(4) N}methylzirconium(IV)
por: MacMillan, Samantha N., et al.
Publicado: (2008)

N (4),N (6)-Dimethyl-5-nitro-N (4),N (6)-diphenylpyrimidine-4,6-diamine
por: Shi, Fuqiang, et al.
Publicado: (2011)

4-Bromo-N (2),N (2),N (6),N (6)-tetraethylpyridine-2,6-dicarboxamide
por: de Lill, Daniel T., et al.
Publicado: (2010)

MicroRNA-545-5p regulates apoptosis, migration and invasion of osteosarcoma by targeting dimethyladenosine transferase 1
por: Zhou, Hai-Zhen, et al.
Publicado: (2021)

N (2),N (2),N (4),N (4),N (6),N (6)-Hexapropyl-1,3,5-triazine-2,4,6-triamine
por: Li, Yu-Feng, et al.
Publicado: (2008)

N2OAs 6
por: Cyvoct, G, et al.
Publicado: (1992)

N (2),N (2),N (6),N (6)-Tetrakis(2,3,4,5,6-pentafluorobenzoyl)pyridine-2,6-diamine
por: Valkonen, Arto, et al.
Publicado: (2011)

Treatment of DIHS/DRESS syndrome with combined N-acetylcysteine, prednisone and valganciclovir – a hypothesis
por: Moling, Oswald, et al.
Publicado: (2012)

Thiasporines A–C, Thiazine and Thiazole Derivatives from a Marine-Derived Actinomycetospora chlora
por: Fu, Peng, et al.
Publicado: (2015)

Exploring the adsorption ability with sensitivity and reactivity of C(12)–B(6)N(6), C(12)–Al(6)N(6), and B(6)N(6)–Al(6)N(6) heteronanocages towards the cisplatin drug: a DFT, AIM, and COSMO analysis
por: Muktadir, Md. Golam, et al.
Publicado: (2022)

(2,2′-Bipyridine-6,6′-dicarboxylato-κ(3) N,N′,O (6))(6′-carboxy-2,2′-bipyridine-6-carboxylato-κ(3) N,N′,O (6))cobalt(III)
por: Wang, Huimin, et al.
Publicado: (2012)

(2,2′-Bipyridine-6,6′-dicarboxylato-κ(3) N,N′,O (6))(6′-carboxy-2,2′-bipyridine-6-carboxylato-κ(3) N,N′,O (6))rhodium(III)
por: Wang, Huimin, et al.
Publicado: (2012)

$^{8}He$ $\beta$-decay to the $^{6}Li+n+n$ channel
por: Shulgina, N B, et al.
Publicado: (1997)

N,N′-Diethyl-N,N′-diphenylpyridine-2,6-dicarboxamide
por: Klepetářová, Blanka, et al.
Publicado: (2012)

N,N,N′,N′-Tetraethylpyridine-2,6-dicarboxamide
por: Pojarová, Michaela, et al.
Publicado: (2011)

N,N,N′,N′-Tetraisobutylpyridine-2,6-dicarboxamide
por: Pojarová, Michaela, et al.
Publicado: (2011)

Coumarin Derivative N6 as a Novel anti-hantavirus Infection Agent Targeting AKT
por: Li, Zhoupeng, et al.
Publicado: (2021)

Photoredox α-Vinylation of α-Amino Acids and N-Aryl Amines
por: Noble, Adam, et al.
Publicado: (2014)

FTO-Mediated Formation of N(6)-Hydroxymethyladenosine and N(6)-Formyladenosine in Mammalian RNA
por: Fu, Ye, et al.
Publicado: (2013)

Study on Pyrolytic Mechanisms of n-Perfluorosilanes Si(n)F(2n+2) (2 ≤ n < 6) and Perfluorocyclosilanes Si(n)F(2n) (3 ≤ n ≤ 6)
por: Zhao, Yuhan, et al.
Publicado: (2021)

Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B
por: Potts, Malia B., et al.
Publicado: (2015)

Spithioneines A and B, Two New Bohemamine Derivatives Possessing Ergothioneine Moiety from a Marine-Derived Streptomyces spinoverrucosus
por: Fu, Peng, et al.
Publicado: (2015)

N,N'-(Hexane-1,6-diyl)bis(4-methyl-N-(oxiran-2-ylmethyl)benzenesulfonamide): Synthesis via cyclodextrin mediated N-alkylation in aqueous solution and further Prilezhaev epoxidation
por: Fischer, Julian, et al.
Publicado: (2013)

N-(2,6-Dimethylphenyl)-N′-propanoylthiourea
por: Yusof, Mohd Sukeri Mohd, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_4eqllr1obo5h8t64a5koe553jv