Activation of Ras-ERK Signaling and GSK-3 by Amyloid Precursor Protein and Amyloid Beta Facilitates Neurodegeneration in Alzheimer’s Disease

It is widely accepted that amyloid β (Aβ) generated from amyloid precursor protein (APP) oligomerizes and fibrillizes to form neuritic plaques in Alzheimer’s disease (AD), yet little is known about the contribution of APP to intracellular signaling events preceding AD pathogenesis. The data presente...

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Detalles Bibliográficos
Autores principales: Kirouac, Lisa, Rajic, Alexander J., Cribbs, David H., Padmanabhan, Jaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2017
Materias:
New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367084/
https://www.ncbi.nlm.nih.gov/pubmed/28374012
http://dx.doi.org/10.1523/ENEURO.0149-16.2017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367084/
https://www.ncbi.nlm.nih.gov/pubmed/28374012
http://dx.doi.org/10.1523/ENEURO.0149-16.2017

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