A pH-responsive prodrug delivery system of 10-HCPT for controlled release and tumor targeting

We synthesized a pH-responsive conjugate of 10-hydroxycamptothecin-thiosemicarbazide-linear polyethylene glycol 2000 (PEG2000). The conjugate was confirmed by matrix-assisted laser desorption time of flight mass spectrometry, (1)H NMR, and (13)C NMR. The water solubility of the prodrug was increased...

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Detalles Bibliográficos
Autores principales: Liu, Yang, Li, Dan, Guo, Xinhong, Xu, Haiwei, Li, Zhi, Zhang, Yanling, Song, Chuanjun, Fan, Ruhan, Tang, Xing, Zhang, Zhenzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367588/
https://www.ncbi.nlm.nih.gov/pubmed/28356739
http://dx.doi.org/10.2147/IJN.S125849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367588/
https://www.ncbi.nlm.nih.gov/pubmed/28356739
http://dx.doi.org/10.2147/IJN.S125849

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