Cargando…

A pH-responsive prodrug delivery system of 10-HCPT for controlled release and tumor targeting

We synthesized a pH-responsive conjugate of 10-hydroxycamptothecin-thiosemicarbazide-linear polyethylene glycol 2000 (PEG2000). The conjugate was confirmed by matrix-assisted laser desorption time of flight mass spectrometry, (1)H NMR, and (13)C NMR. The water solubility of the prodrug was increased...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Yang, Li, Dan, Guo, Xinhong, Xu, Haiwei, Li, Zhi, Zhang, Yanling, Song, Chuanjun, Fan, Ruhan, Tang, Xing, Zhang, Zhenzhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367588/ https://www.ncbi.nlm.nih.gov/pubmed/28356739 http://dx.doi.org/10.2147/IJN.S125849

Ejemplares similares

Pharmacokinetics of a ternary conjugate based pH-responsive 10-HCPT prodrug nano-micelle delivery system
por: Liu, Yang, et al.
Publicado: (2017)

10-Hydroxycamptothecin (HCPT) nanosuspensions stabilized by mPEG(1000)-HCPT conjugate: high stabilizing efficiency and improved antitumor efficacy
por: Yang, Linjie, et al.
Publicado: (2017)

Evaluation of self-assembled HCPT-loaded PEG-b-PLA nanoparticles by comparing with HCPT-loaded PLA nanoparticles
por: Yang, Xiangrui, et al.
Publicado: (2014)

Preparation and Physicochemical Properties of 10-Hydroxycamptothecin (HCPT) Nanoparticles by Supercritical Antisolvent (SAS) Process
por: Zhao, Xiuhua, et al.
Publicado: (2011)

A pH-Sensitive Prodrug Nanocarrier Based on Diosgenin for Doxorubicin Delivery to Efficiently Inhibit Tumor Metastasis
por: Wei, Zeliang, et al.
Publicado: (2020)

Overexpression of the HcPT1.1 transporter in Hebeloma cylindrosporum alters the phosphorus accumulation of Pinus pinaster and the distribution of HcPT2 in ectomycorrhizae
por: Amenc, Laurie, et al.
Publicado: (2023)

Preparation of HCPT-Loaded Nanoneedles with Pointed Ends for Highly Efficient Cancer Chemotherapy
por: Wu, Shichao, et al.
Publicado: (2016)

Co-Delivery of Paclitaxel and Doxorubicin by pH-Responsive Prodrug Micelles for Cancer Therapy
por: Jiang, Yanhua, et al.
Publicado: (2020)

Design, preparation and pharmacodynamics of ICG-Fe(Ⅲ) based HCPT nanocrystals against cancer
por: Ren, Qiongzhe, et al.
Publicado: (2022)

Co-delivery of doxorubicin and curcumin by pH-sensitive prodrug nanoparticle for combination therapy of cancer
por: Zhang, Yumin, et al.
Publicado: (2016)

59 Hyperosmolar Conjunctival Provocation Test (HCPT) in the Evaluation of Ocular Symptoms
por: Mercer Mourão, Elizabeth Maria, et al.
Publicado: (2012)

Fluorescent Imaging-Guided Chemo- and Photodynamic Therapy of Hepatocellular Carcinoma with HCPT@NMOFs-RGD Nanocomposites
por: Shang, Yue, et al.
Publicado: (2022)

Mineralization of pH-Sensitive Doxorubicin Prodrug in ZIF-8 to Enable Targeted Delivery to Solid Tumors
por: Yan, Jiaqi, et al.
Publicado: (2020)

Integrated prodrug micelles with two-photon bioimaging and pH-triggered drug delivery for cancer theranostics
por: Xu, Hong, et al.
Publicado: (2020)

Construction of a Phenylboronic Acid-Functionalized Nano-Prodrug for pH-Responsive Emodin Delivery and Antibacterial Activity
por: Zheng, Guodong, et al.
Publicado: (2021)

Design of pH-sensitive methotrexate prodrug-targeted curcumin nanoparticles for efficient dual-drug delivery and combination cancer therapy
por: Xie, Jiajiang, et al.
Publicado: (2018)

Self-Assembly of pH-Labile Polymer Nanoparticles for Paclitaxel Prodrug Delivery: Formulation, Characterization, and Evaluation
por: Levit, Shani L., et al.
Publicado: (2020)

A pH-Responsive Zwitterionic Polyurethane Prodrug as Drug Delivery System for Enhanced Cancer Therapy
por: He, Qian, et al.
Publicado: (2021)

The design and synthesis of dextran-doxorubicin prodrug-based pH-sensitive drug delivery system for improving chemotherapy efficacy
por: Zhang, Xiaoli, et al.
Publicado: (2020)

Dual-targeted and pH-sensitive Doxorubicin Prodrug-Microbubble Complex with Ultrasound for Tumor Treatment
por: Luo, Wanxian, et al.
Publicado: (2017)

ROS-Responsive and pH-Sensitive Aminothiols Dual-Prodrug for Radiation Enteritis
por: Chen, Yuanfang, et al.
Publicado: (2022)

pH and ROS sequentially responsive podophyllotoxin prodrug micelles with surface charge-switchable and self-amplification drug release for combating multidrug resistance cancer
por: Li, Chao, et al.
Publicado: (2021)

Acetal-Linked Paclitaxel Polymeric Prodrug Based on Functionalized mPEG-PCL Diblock Polymer for pH-Triggered Drug Delivery
por: Zhai, Yinglei, et al.
Publicado: (2017)

The Natural Compound Climacostol as a Prodrug Strategy Based on pH Activation for Efficient Delivery of Cytotoxic Small Agents
por: Catalani, Elisabetta, et al.
Publicado: (2019)

pH-Responsive Artesunate Polymer Prodrugs with Enhanced Ablation Effect on Rodent Xenograft Colon Cancer
por: Hao, Dan-Li, et al.
Publicado: (2020)

Manganese dioxide nanosheets-based redox/pH-responsive drug delivery system for cancer theranostic application
por: Hao, Yongwei, et al.
Publicado: (2016)

A pH-responsive liposomal nanoplatform for co-delivery of a Pt(IV) prodrug and cinnamaldehyde for effective tumor therapy
por: Tang, Ting, et al.
Publicado: (2023)

Genistein Sensitizes Bladder Cancer Cells to HCPT Treatment In Vitro and In Vivo via ATM/NF-κB/IKK Pathway-Induced Apoptosis
por: Wang, Yong, et al.
Publicado: (2013)

Brain Delivery of Thyrotropin-Releasing Hormone via a Novel Prodrug Approach
por: Prokai-Tatrai, Katalin, et al.
Publicado: (2019)

pH/redox sensitive nanoparticles with platinum(iv) prodrugs and doxorubicin enhance chemotherapy in ovarian cancer
por: Zhang, Guyu, et al.
Publicado: (2019)

Dual pH/Redox-Responsive Mixed Polymeric Micelles for Anticancer Drug Delivery and Controlled Release
por: Luo, Yongle, et al.
Publicado: (2019)

A Co-delivery System Based on a Dimeric Prodrug and Star-Shaped Polymeric Prodrug Micelles for Drug Delivery
por: Zhou, Man, et al.
Publicado: (2021)

Benzotriazine Di-Oxide Prodrugs for Exploiting Hypoxia and Low Extracellular pH in Tumors
por: Hay, Michael P., et al.
Publicado: (2019)

Therapeutic effect of pH-Responsive dexamethasone prodrug nanoparticles on acute lung injury
por: Su, Meiling, et al.
Publicado: (2021)

pH-sensitive charge-conversion cinnamaldehyde polymeric prodrug micelles for effective targeted chemotherapy of osteosarcoma in vitro
por: Deng, Jiapeng, et al.
Publicado: (2023)

pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery
por: Juthi, Ajkia Zaman, et al.
Publicado: (2023)

Sodium dodecyl sulfate/β-cyclodextrin vesicles embedded in chitosan gel for insulin delivery with pH-selective release
por: Li, Zhuo, et al.
Publicado: (2016)

Activation and Delivery of Tetrazine-Responsive Bioorthogonal Prodrugs
por: Wang, Yayue, et al.
Publicado: (2020)

Engineered bovine serum albumin-based nanoparticles with pH-sensitivity for doxorubicin delivery and controlled release
por: Yang, Zhihang, et al.
Publicado: (2020)

pH-Sensitive Biomaterials for Drug Delivery
por: Zhuo, Shijie, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_u0dnesqjhn75ff39eg7dnroph1