Parameter estimation for multistage clonal expansion models from cancer incidence data: A practical identifiability analysis

Many cancers are understood to be the product of multiple somatic mutations or other rate-limiting events. Multistage clonal expansion (MSCE) models are a class of continuous-time Markov chain models that capture the multi-hit initiation–promotion–malignant-conversion hypothesis of carcinogenesis. T...

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Detalles Bibliográficos
Autores principales: Brouwer, Andrew F., Meza, Rafael, Eisenberg, Marisa C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367820/
https://www.ncbi.nlm.nih.gov/pubmed/28288156
http://dx.doi.org/10.1371/journal.pcbi.1005431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367820/
https://www.ncbi.nlm.nih.gov/pubmed/28288156
http://dx.doi.org/10.1371/journal.pcbi.1005431

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