Knock-in of Cx46 partially rescues fiber defects in lenses lacking Cx50

PURPOSE: Connexins 46 (Cx46) and 50 (Cx50) support lens development and homeostasis. Knockout (KO) of Cx50, but not Cx46, causes defects in lens fiber organization, F-actin enrichment, gap junction (GJ) size, ball-and-socket (BS) maturation, and GJ-associated protein distributions. To further determ...

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Detalles Bibliográficos
Autores principales: Wang, Eddie, Geng, Andrew, Seo, Richard, Maniar, Ankur, Gong, Xiaohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367893/
https://www.ncbi.nlm.nih.gov/pubmed/28458505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367893/
https://www.ncbi.nlm.nih.gov/pubmed/28458505

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