Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells

Recently, we showed that generation of tumours in syngeneic mice by cells devoid of mitochondrial (mt) DNA (ρ(0) cells) is linked to the acquisition of the host mtDNA. However, the mechanism of mtDNA movement between cells remains unresolved. To determine whether the transfer of mtDNA involves whole...

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Detalles Bibliográficos
Autores principales: Dong, Lan-Feng, Kovarova, Jaromira, Bajzikova, Martina, Bezawork-Geleta, Ayenachew, Svec, David, Endaya, Berwini, Sachaphibulkij, Karishma, Coelho, Ana R, Sebkova, Natasa, Ruzickova, Anna, Tan, An S, Kluckova, Katarina, Judasova, Kristyna, Zamecnikova, Katerina, Rychtarcikova, Zuzana, Gopalan, Vinod, Andera, Ladislav, Sobol, Margarita, Yan, Bing, Pattnaik, Bijay, Bhatraju, Naveen, Truksa, Jaroslav, Stopka, Pavel, Hozak, Pavel, Lam, Alfred K, Sedlacek, Radislav, Oliveira, Paulo J, Kubista, Mikael, Agrawal, Anurag, Dvorakova-Hortova, Katerina, Rohlena, Jakub, Berridge, Michael V, Neuzil, Jiri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367896/
https://www.ncbi.nlm.nih.gov/pubmed/28195532
http://dx.doi.org/10.7554/eLife.22187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367896/
https://www.ncbi.nlm.nih.gov/pubmed/28195532
http://dx.doi.org/10.7554/eLife.22187

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