Cyclized Oligopeptide Targeting LRP5/6-DKK1 Interaction Reduces the Growth of Tumor Burden in a Multiple Myeloma Mouse Model

PURPOSE: Dickkopf 1 (DKK1) has been extensively investigated in mouse models of multiple myeloma, which results in osteolytic bone lesions. Elevated DKK1 levels in bone marrow plasma and serum inhibit the differentiation of osteoblast precursors. Present pharmaceutical approaches to target bone lesi...

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Detalles Bibliográficos
Autores principales: Park, Bo Mi, Kim, Eun Jin, Nam, Hee Jin, Zhang, Dongdong, Bae, Chu Hyun, Kang, Myeongmo, Kim, Heeyoun, Lee, Weontae, Bogen, Bjarne, Lim, Sung-Kil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368134/
https://www.ncbi.nlm.nih.gov/pubmed/28332354
http://dx.doi.org/10.3349/ymj.2017.58.3.505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368134/
https://www.ncbi.nlm.nih.gov/pubmed/28332354
http://dx.doi.org/10.3349/ymj.2017.58.3.505

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