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Reduction of Huntington’s Disease RNA Foci by CAG Repeat-Targeting Reagents
In several human polyglutamine diseases caused by expansions of CAG repeats in the coding sequence of single genes, mutant transcripts are detained in nuclear RNA foci. In polyglutamine disorders, unlike other repeat-associated diseases, both RNA and proteins exert pathogenic effects; therefore, dec...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368221/ https://www.ncbi.nlm.nih.gov/pubmed/28400719 http://dx.doi.org/10.3389/fncel.2017.00082 |