Deletion of TRPC6 Attenuates NMDA Receptor-Mediated Ca(2+) Entry and Ca(2+)-Induced Neurotoxicity Following Cerebral Ischemia and Oxygen-Glucose Deprivation

Transient receptor potential canonical 6 (TRPC6) channels are permeable to Na(+) and Ca(2+) and are widely expressed in the brain. In this study, the role of TRPC6 was investigated following ischemia/reperfusion (I/R) and oxygen-glucose deprivation (OGD). We found that TRPC6 expression was increased...

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Detalles Bibliográficos
Autores principales: Chen, Jin, Li, Zhaozhong, Hatcher, Jeffery T., Chen, Qing-Hui, Chen, Li, Wurster, Robert D., Chan, Sic L., Cheng, Zixi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368256/
https://www.ncbi.nlm.nih.gov/pubmed/28400714
http://dx.doi.org/10.3389/fnins.2017.00138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368256/
https://www.ncbi.nlm.nih.gov/pubmed/28400714
http://dx.doi.org/10.3389/fnins.2017.00138

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