T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP

The ATP-gated ionotropic P2X7 receptor regulates T follicular helper (Tfh) cell abundance in the Peyer’s patches (PPs) of the small intestine; deletion of P2rx7, encoding for P2X7, in Tfh cells results in enhanced IgA secretion and binding to commensal bacteria. Here, we show that Tfh cell activity...

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Detalles Bibliográficos
Autores principales: Perruzza, Lisa, Gargari, Giorgio, Proietti, Michele, Fosso, Bruno, D’Erchia, Anna Maria, Faliti, Caterina Elisa, Rezzonico-Jost, Tanja, Scribano, Daniela, Mauri, Laura, Colombo, Diego, Pellegrini, Giovanni, Moregola, Annalisa, Mooser, Catherine, Pesole, Graziano, Nicoletti, Mauro, Norata, Giuseppe Danilo, Geuking, Markus B., McCoy, Kathy D., Guglielmetti, Simone, Grassi, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368345/
https://www.ncbi.nlm.nih.gov/pubmed/28297661
http://dx.doi.org/10.1016/j.celrep.2017.02.061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368345/
https://www.ncbi.nlm.nih.gov/pubmed/28297661
http://dx.doi.org/10.1016/j.celrep.2017.02.061

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