T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP

The ATP-gated ionotropic P2X7 receptor regulates T follicular helper (Tfh) cell abundance in the Peyer’s patches (PPs) of the small intestine; deletion of P2rx7, encoding for P2X7, in Tfh cells results in enhanced IgA secretion and binding to commensal bacteria. Here, we show that Tfh cell activity...

Descripción completa

Detalles Bibliográficos
Autores principales: Perruzza, Lisa, Gargari, Giorgio, Proietti, Michele, Fosso, Bruno, D’Erchia, Anna Maria, Faliti, Caterina Elisa, Rezzonico-Jost, Tanja, Scribano, Daniela, Mauri, Laura, Colombo, Diego, Pellegrini, Giovanni, Moregola, Annalisa, Mooser, Catherine, Pesole, Graziano, Nicoletti, Mauro, Norata, Giuseppe Danilo, Geuking, Markus B., McCoy, Kathy D., Guglielmetti, Simone, Grassi, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368345/
https://www.ncbi.nlm.nih.gov/pubmed/28297661
http://dx.doi.org/10.1016/j.celrep.2017.02.061

Ejemplares similares

Ejemplares similares