Dendritic Cells Cross-Present Immunogenic Lentivector-Encoded Antigen from Transduced Cells to Prime Functional T Cell Immunity

Recombinant lentiviral vectors (LVs) are highly effective vaccination vehicles that elicit protective T cell immunity in disease models. Dendritic cells (DCs) acquire antigen at sites of vaccination and migrate to draining lymph nodes, where they prime vaccine-specific T cells. The potency with whic...

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Detalles Bibliográficos
Autores principales: Hotblack, Alastair, Seshadri, Sara, Zhang, Lei, Hamrang-Yousefi, Sahar, Chakraverty, Ronjon, Escors, David, Bennett, Clare L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368353/
https://www.ncbi.nlm.nih.gov/pubmed/28153097
http://dx.doi.org/10.1016/j.ymthe.2016.11.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368353/
https://www.ncbi.nlm.nih.gov/pubmed/28153097
http://dx.doi.org/10.1016/j.ymthe.2016.11.001

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