Selective Blockade of the Ubiquitous Checkpoint Receptor CD47 Is Enabled by Dual-Targeting Bispecific Antibodies

CD47 is a ubiquitously expressed immune checkpoint receptor that is often upregulated in cancer. CD47 interacts with its counter-receptor SIRPα on macrophages and other myeloid cells to inhibit cancer cell phagocytosis and drive immune evasion. To overcome tolerability and “antigen sink” issues aris...

Descripción completa

Detalles Bibliográficos
Autores principales: Dheilly, Elie, Moine, Valéry, Broyer, Lucile, Salgado-Pires, Susana, Johnson, Zoë, Papaioannou, Anne, Cons, Laura, Calloud, Sébastien, Majocchi, Stefano, Nelson, Robert, Rousseau, François, Ferlin, Walter, Kosco-Vilbois, Marie, Fischer, Nicolas, Masternak, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368402/
https://www.ncbi.nlm.nih.gov/pubmed/28153099
http://dx.doi.org/10.1016/j.ymthe.2016.11.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368402/
https://www.ncbi.nlm.nih.gov/pubmed/28153099
http://dx.doi.org/10.1016/j.ymthe.2016.11.006

Ejemplares similares