Cargando…

Selective Blockade of the Ubiquitous Checkpoint Receptor CD47 Is Enabled by Dual-Targeting Bispecific Antibodies

CD47 is a ubiquitously expressed immune checkpoint receptor that is often upregulated in cancer. CD47 interacts with its counter-receptor SIRPα on macrophages and other myeloid cells to inhibit cancer cell phagocytosis and drive immune evasion. To overcome tolerability and “antigen sink” issues aris...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dheilly, Elie, Moine, Valéry, Broyer, Lucile, Salgado-Pires, Susana, Johnson, Zoë, Papaioannou, Anne, Cons, Laura, Calloud, Sébastien, Majocchi, Stefano, Nelson, Robert, Rousseau, François, Ferlin, Walter, Kosco-Vilbois, Marie, Fischer, Nicolas, Masternak, Krzysztof
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368402/ https://www.ncbi.nlm.nih.gov/pubmed/28153099 http://dx.doi.org/10.1016/j.ymthe.2016.11.006

Ejemplares similares

Tumor-Directed Blockade of CD47 with Bispecific Antibodies Induces Adaptive Antitumor Immunity
por: Dheilly, Elie, et al.
Publicado: (2018)

Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG
por: Fischer, Nicolas, et al.
Publicado: (2015)

Targeting a membrane-proximal epitope on mesothelin increases the tumoricidal activity of a bispecific antibody blocking CD47 on mesothelin-positive tumors
por: Hatterer, Eric, et al.
Publicado: (2020)

CD47xCD19 bispecific antibody triggers recruitment and activation of innate immune effector cells in a B-cell lymphoma xenograft model
por: Chauchet, Xavier, et al.
Publicado: (2022)

Interferon gamma (IFNg) production is associated to disease parameters in TLR9-induced secondary hemophagocytic lymphohistiocytosis (sHLH) in mice
por: De Min, Cristina, et al.
Publicado: (2014)

Co-engaging CD47 and CD19 with a bispecific antibody abrogates B-cell receptor/CD19 association leading to impaired B-cell proliferation
por: Hatterer, Eric, et al.
Publicado: (2019)

Interferon gamma (IFNg) drives disease in the TLR9-mediated cytokine storm syndrome in mice
por: de Min, C, et al.
Publicado: (2015)

Transferring the Characteristics of Naturally Occurring and Biased Antibody Repertoires to Human Antibody Libraries by Trapping CDRH3 Sequences
por: Venet, Sophie, et al.
Publicado: (2012)

Use of a mouse model to identify a blood biomarker for IFNγ activity in pediatric secondary hemophagocytic lymphohistiocytosis
por: Buatois, Vanessa, et al.
Publicado: (2017)

Dual checkpoint blockade of CD47 and PD-L1 using an affinity-tuned bispecific antibody maximizes antitumor immunity
por: Chen, Shih-Hsun, et al.
Publicado: (2021)

Blockade of dual immune checkpoint inhibitory signals with a CD47/PD-L1 bispecific antibody for cancer treatment
por: Wang, Rongjuan, et al.
Publicado: (2023)

Dual blockade of CD47 and CD24 signaling using a novel bispecific antibody fusion protein enhances macrophage immunotherapy
por: Yang, Yun, et al.
Publicado: (2023)

Potential Role of CD47-Directed Bispecific Antibodies in Cancer Immunotherapy
por: Yang, Yan, et al.
Publicado: (2021)

Maximizing the potency of an anti-TLR4 monoclonal antibody by exploiting proximity to Fcγ receptors: Fc-mediated avidity enhances the potency of an anti-TLR4 antibody
por: Loyau, Jérémy, et al.
Publicado: (2014)

Enhanced Follicular Dendritic Cell-B Cell Interaction in HIV and SIV Infections and its Potential Role in Polyclonal B Cell Activation
por: Rosenberg, Yvonne J., et al.
Publicado: (1998)

Cell-type specific potent Wnt signaling blockade by bispecific antibody
por: Lee, Nam-Kyung, et al.
Publicado: (2018)

P871: ISB 1442, A FIRST-IN-CLASS CD38 AND CD47 BISPECIFIC ANTIBODY INNATE CELL MODULATOR FOR THE TREATMENT OF CD38 POSITIVE HEMATOLOGICAL MALIGNANCIES
por: Grandclement, C., et al.
Publicado: (2022)

Neutralization of IFNγ defeats haemophagocytosis in LCMV-infected perforin- and Rab27a-deficient mice
por: Schmid, Jana Pachlopnik, et al.
Publicado: (2009)

Bispecific antibody approach for EGFR-directed blockade of the CD47-SIRPα “don’t eat me” immune checkpoint promotes neutrophil-mediated trogoptosis and enhances antigen cross-presentation
por: Hendriks, Mark A. J. M., et al.
Publicado: (2020)

Rationale for Combining Bispecific T Cell Activating Antibodies With Checkpoint Blockade for Cancer Therapy
por: Kobold, Sebastian, et al.
Publicado: (2018)

Germinal Center Formation and Local Immunoglobulin E (IgE) Production in the Lung after an Airway Antigenic Challenge
por: Chvatchko, Yolande, et al.
Publicado: (1996)

Interleukin 6 Influences Germinal Center Development and Antibody Production via a Contribution of C3 Complement Component
por: Kopf, Manfred, et al.
Publicado: (1998)

The Sequential Role of Lymphotoxin and B Cells in the Development of Splenic Follicles
por: Gonzalez, Mercedes, et al.
Publicado: (1998)

CD47 Blockade Triggers T cell-mediated Destruction of Immunogenic Tumors
por: Liu, Xiaojuan, et al.
Publicado: (2015)

A Novel Blockade CD47 Antibody With Therapeutic Potential for Cancer
por: Lin, Fangzhen, et al.
Publicado: (2021)

CD47 blockade enhances phagocytosis of cardiac cell debris by neutrophils
por: Haj-Yehia, Elias, et al.
Publicado: (2023)

Genome analysis of the ubiquitous boxwood pathogen Pseudonectria foliicola
por: Rivera, Yazmín, et al.
Publicado: (2018)

CD47 blockade inhibits tumor progression human osteosarcoma in xenograft models
por: Xu, Ji-Feng, et al.
Publicado: (2015)

Synergistic effect of CD47 blockade in combination with cordycepin treatment against cancer
por: Feng, Chen, et al.
Publicado: (2023)

The ubiquitous quasidisk
por: Gehring, Frederick W, et al.
Publicado: (2012)

Ubiquitous Amyloids
por: Pulawski, Wojciech, et al.
Publicado: (2012)

Deriving a germinal center lymphocyte migration model from two-photon data
por: Figge, Marc Thilo, et al.
Publicado: (2008)

A Member of the Dendritic Cell Family That Enters B Cell Follicles and Stimulates Primary Antibody Responses Identified by a Mannose Receptor Fusion Protein
por: Berney, Claude, et al.
Publicado: (1999)

Therapeutic Effects of Treatment with Anti-TLR2 and Anti-TLR4 Monoclonal Antibodies in Polymicrobial Sepsis
por: Lima, Cristiano Xavier, et al.
Publicado: (2015)

Bispecific T cell engagers kill resistant cells during KRAS-G12C blockade therapy
por: Song, Xinxin, et al.
Publicado: (2022)

Blockade of CD47 increases survival of mice exposed to lethal total body irradiation
por: Soto-Pantoja, David R., et al.
Publicado: (2013)

Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells
por: Candas-Green, Demet, et al.
Publicado: (2020)

CD47 blockade enhances the efficacy of intratumoral STING-targeting therapy by activating phagocytes
por: Kosaka, Akemi, et al.
Publicado: (2021)

Radiotherapy in combination with CD47 blockade elicits a macrophage-mediated abscopal effect
por: Nishiga, Yoko, et al.
Publicado: (2022)

CD47 blockade ameliorates autoimmune vasculitis via efferocytosis of neutrophil extracellular traps
por: Shiratori-Aso, Satoka, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_qgcdifted893tt8v4qgsatv0mr