The nicotinic acetylcholine receptor α7 subunit is an essential negative regulator of bone mass

The nicotinic receptor α7nAchR reportedly regulates vagal nerve targets in brain and cardiac tissue. Here we show that nAchR7(−/−) mice exhibit increased bone mass due to decreased osteoclast formation, accompanied by elevated osteoprotegerin/RANKL ratios in serum. Vagotomy in wild-type mice also si...

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Detalles Bibliográficos
Autores principales: Mito, Kazuaki, Sato, Yuiko, Kobayashi, Tami, Miyamoto, Kana, Nitta, Eriko, Iwama, Atsushi, Matsumoto, Morio, Nakamura, Masaya, Sato, Kazuki, Miyamoto, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368561/
https://www.ncbi.nlm.nih.gov/pubmed/28349965
http://dx.doi.org/10.1038/srep45597

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368561/
https://www.ncbi.nlm.nih.gov/pubmed/28349965
http://dx.doi.org/10.1038/srep45597

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