Structural Basis for pH-mediated Regulation of F-actin Severing by Gelsolin Domain 1

Six-domain gelsolin regulates actin structural dynamics through its abilities to sever, cap and uncap F-actin. These activities are modulated by various cellular parameters like Ca(2+) and pH. Until now, only the molecular activation mechanism of gelsolin by Ca(2+) has been understood relatively wel...

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Detalles Bibliográficos
Autores principales: Fan, Jing-song, Goh, Honzhen, Ding, Ke, Xue, Bo, Robinson, Robert C., Yang, Daiwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368644/
https://www.ncbi.nlm.nih.gov/pubmed/28349924
http://dx.doi.org/10.1038/srep45230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368644/
https://www.ncbi.nlm.nih.gov/pubmed/28349924
http://dx.doi.org/10.1038/srep45230

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