Neurotoxic Doses of Chronic Methamphetamine Trigger Retrotransposition of the Identifier Element in Rat Dorsal Dentate Gyrus

Short interspersed elements (SINEs) are typically silenced by DNA hypermethylation in somatic cells, but can retrotranspose in proliferating cells during adult neurogenesis. Hypomethylation caused by disease pathology or genotoxic stress leads to genomic instability of SINEs. The goal of the present...

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Detalles Bibliográficos
Autores principales: Moszczynska, Anna, Burghardt, Kyle J., Yu, Dongyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368700/
https://www.ncbi.nlm.nih.gov/pubmed/28272323
http://dx.doi.org/10.3390/genes8030096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368700/
https://www.ncbi.nlm.nih.gov/pubmed/28272323
http://dx.doi.org/10.3390/genes8030096

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