Therapeutically targeting guanylate cyclase‐C: computational modeling of plecanatide, a uroguanylin analog

Plecanatide is a recently developed guanylate cyclase‐C (GC‐C) agonist and the first uroguanylin analog designed to treat chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS‐C). GC‐C receptors are found across the length of the intestines and are thought to play...

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Detalles Bibliográficos
Autores principales: Brancale, Andrea, Shailubhai, Kunwar, Ferla, Salvatore, Ricci, Antonio, Bassetto, Marcella, Jacob, Gary S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368960/
https://www.ncbi.nlm.nih.gov/pubmed/28357122
http://dx.doi.org/10.1002/prp2.295

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368960/
https://www.ncbi.nlm.nih.gov/pubmed/28357122
http://dx.doi.org/10.1002/prp2.295

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