Expanding metabolic pathway for de novo biosynthesis of the chiral pharmaceutical intermediate l-pipecolic acid in Escherichia coli

BACKGROUND: The six-carbon circular non-proteinogenic compound l-pipecolic acid is an important chiral drug intermediate with many applications in the pharmaceutical industry. In the present study, we developed a metabolically engineered strain of Escherichia coli for the overproduction of l-pipecol...

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Detalles Bibliográficos
Autores principales: Ying, Hanxiao, Tao, Sha, Wang, Jing, Ma, Weichao, Chen, Kequan, Wang, Xin, Ouyang, Pingkai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369227/
https://www.ncbi.nlm.nih.gov/pubmed/28347340
http://dx.doi.org/10.1186/s12934-017-0666-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369227/
https://www.ncbi.nlm.nih.gov/pubmed/28347340
http://dx.doi.org/10.1186/s12934-017-0666-0

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