Label-free target identification using in-gel fluorescence difference via thermal stability shift

Target engagement is a prerequisite for the therapeutic effects of bioactive small molecules, and unbiased identification of their target proteins can facilitate drug discovery and chemical biology research. Structural modifications of bioactive natural products for target identification exhibit pot...

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Detalles Bibliográficos
Autores principales: Park, Hankum, Ha, Jaeyoung, Koo, Ja Young, Park, Jongmin, Park, Seung Bum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369521/
https://www.ncbi.nlm.nih.gov/pubmed/28451252
http://dx.doi.org/10.1039/c6sc03238a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369521/
https://www.ncbi.nlm.nih.gov/pubmed/28451252
http://dx.doi.org/10.1039/c6sc03238a

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