Cargando…
Label-free target identification using in-gel fluorescence difference via thermal stability shift
Target engagement is a prerequisite for the therapeutic effects of bioactive small molecules, and unbiased identification of their target proteins can facilitate drug discovery and chemical biology research. Structural modifications of bioactive natural products for target identification exhibit pot...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369521/ https://www.ncbi.nlm.nih.gov/pubmed/28451252 http://dx.doi.org/10.1039/c6sc03238a |