Substrate selectivity of an isolated enoyl reductase catalytic domain from an iterative highly reducing fungal polyketide synthase reveals key components of programming

A cis-acting enoyl reductase (ER) catalytic domain was isolated from a fungal highly reducing iterative polyketide synthase (HR-iPKS) for the first time and studied in vitro. The ER from the squalestatin tetraketide synthase forms a discrete dimeric protein in solution. The ER shows broad substrate...

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Detalles Bibliográficos
Autores principales: Roberts, Douglas M., Bartel, Christoph, Scott, Alan, Ivison, David, Simpson, Thomas J., Cox, Russell J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369529/
https://www.ncbi.nlm.nih.gov/pubmed/28451251
http://dx.doi.org/10.1039/c6sc03496a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369529/
https://www.ncbi.nlm.nih.gov/pubmed/28451251
http://dx.doi.org/10.1039/c6sc03496a

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