NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors

There are no clinically useful inhibitors of metallo-β-lactamases (MBLs), which are a growing problem because they hydrolyse almost all β-lactam antibacterials. Inhibition by most reported MBL inhibitors involves zinc ion chelation. A structure-based virtual screening approach combined with NMR filt...

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Detalles Bibliográficos
Autores principales: Li, Guo-Bo, Abboud, Martine I., Brem, Jürgen, Someya, Hidenori, Lohans, Christopher T., Yang, Sheng-Yong, Spencer, James, Wareham, David W., McDonough, Michael A., Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369532/
https://www.ncbi.nlm.nih.gov/pubmed/28451231
http://dx.doi.org/10.1039/c6sc04524c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369532/
https://www.ncbi.nlm.nih.gov/pubmed/28451231
http://dx.doi.org/10.1039/c6sc04524c

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