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Polymorphism at 129 dictates metastable conformations of the human prion protein N-terminal β-sheet
We study the thermodynamic stability of the native state of the human prion protein using a new free-energy method, replica-exchange on-the-fly parameterization. This method is designed to overcome hidden-variable sampling limitations to yield nearly error-free free-energy profiles along a conformat...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369536/ https://www.ncbi.nlm.nih.gov/pubmed/28451263 http://dx.doi.org/10.1039/c6sc03275c |