A fat-derived metabolite regulates a peptidergic feeding circuit in Drosophila

Here, we show that the enzymatic cofactor tetrahydrobiopterin (BH4) inhibits feeding in Drosophila. BH4 biosynthesis requires the sequential action of the conserved enzymes Punch, Purple, and Sepiapterin Reductase (Sptr). Although we observe increased feeding upon loss of Punch and Purple in the adu...

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Detalles Bibliográficos
Autores principales: Kim, Do-Hyoung, Shin, Minjung, Jung, Sung-Hwan, Kim, Young-Joon, Jones, Walton D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369665/
https://www.ncbi.nlm.nih.gov/pubmed/28350856
http://dx.doi.org/10.1371/journal.pbio.2000532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369665/
https://www.ncbi.nlm.nih.gov/pubmed/28350856
http://dx.doi.org/10.1371/journal.pbio.2000532

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