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In vivo histone H1 migration from necrotic to viable tissue

Necrosis is induced by ischemic conditions within the core of many solid tumors. Using fluorescent fusion proteins, we provide in vivo evidence of histone trafficking among cancer cells in implanted tumors. In particular, the most abundant H1 isoform (H1.2) was found to be transported from necrotic...

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Detalles Bibliográficos
Autores principales: Luhrs, Keith A., Pink, Desmond, Schulte, Wendy, Zijlstra, Andries, Lewis, John D., Parseghian, Missag H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369962/
https://www.ncbi.nlm.nih.gov/pubmed/28187445
http://dx.doi.org/10.18632/oncotarget.15181