The HDAC inhibitor AR42 interacts with pazopanib to kill trametinib/dabrafenib-resistant melanoma cells in vitro and in vivo

Studies focused on the killing of activated B-RAF melanoma cells by the histone deacetylase (HDAC) inhibitor AR42. Compared to other tumor cell lines, PDX melanoma isolates were significantly more sensitive to AR42-induced killing. AR42 and the multi-kinase inhibitor pazopanib interacted to activate...

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Detalles Bibliográficos
Autores principales: Booth, Laurence, Roberts, Jane L., Sander, Cindy, Lee, John, Kirkwood, John M., Poklepovic, Andrew, Dent, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369969/
https://www.ncbi.nlm.nih.gov/pubmed/28146421
http://dx.doi.org/10.18632/oncotarget.14829

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369969/
https://www.ncbi.nlm.nih.gov/pubmed/28146421
http://dx.doi.org/10.18632/oncotarget.14829

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