Biophysical characterization of the b-HLH-LZ of ΔMax, an alternatively spliced isoform of Max found in tumor cells: Towards the validation of a tumor suppressor role for the Max homodimers

It is classically recognized that the physiological and oncogenic functions of Myc proteins depend on specific DNA binding enabled by the dimerization of its C-terminal basic-region-Helix-Loop-Helix-Leucine Zipper (b-HLH-LZ) domain with that of Max. However, a new paradigm is emerging, where the bin...

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Detalles Bibliográficos
Autores principales: Maltais, Loïka, Montagne, Martin, Bédard, Mikaël, Tremblay, Cynthia, Soucek, Laura, Lavigne, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370111/
https://www.ncbi.nlm.nih.gov/pubmed/28350847
http://dx.doi.org/10.1371/journal.pone.0174413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370111/
https://www.ncbi.nlm.nih.gov/pubmed/28350847
http://dx.doi.org/10.1371/journal.pone.0174413

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