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Biophysical characterization of the b-HLH-LZ of ΔMax, an alternatively spliced isoform of Max found in tumor cells: Towards the validation of a tumor suppressor role for the Max homodimers
It is classically recognized that the physiological and oncogenic functions of Myc proteins depend on specific DNA binding enabled by the dimerization of its C-terminal basic-region-Helix-Loop-Helix-Leucine Zipper (b-HLH-LZ) domain with that of Max. However, a new paradigm is emerging, where the bin...
Autores principales: | Maltais, Loïka, Montagne, Martin, Bédard, Mikaël, Tremblay, Cynthia, Soucek, Laura, Lavigne, Pierre |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370111/ https://www.ncbi.nlm.nih.gov/pubmed/28350847 http://dx.doi.org/10.1371/journal.pone.0174413 |
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