Codon-level co-occurrences of germline variants and somatic mutations in cancer are rare but often lead to incorrect variant annotation and underestimated impact prediction

Cancer cells explore a broad mutational landscape, bringing the possibility that tumor-specific somatic mutations could fall in the same codons as germline SNVs and leverage their presence to produce substitutions with a larger impact on protein function. While multiple, temporally consecutive mutat...

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Detalles Bibliográficos
Autores principales: Koire, Amanda, Kim, Young Won, Wang, Jarey, Katsonis, Panagiotis, Jin, Haijing, Lichtarge, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370158/
https://www.ncbi.nlm.nih.gov/pubmed/28350864
http://dx.doi.org/10.1371/journal.pone.0174766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370158/
https://www.ncbi.nlm.nih.gov/pubmed/28350864
http://dx.doi.org/10.1371/journal.pone.0174766

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