Prosaposin knockdown in Caco-2 cells decreases cellular levels of coenzyme Q10 and ATP, and results in the loss of tight junction barriers

Coenzyme Q10 (CoQ10) is a key component of the mitochondrial electron transfer chain and is one of the most important antioxidants. We previously found that glycoprotein prosaposin (Psap) binds CoQ10 in human cells. Although Psap is expressed in the intestines, its role in the gastrointestinal tract...

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Detalles Bibliográficos
Autores principales: Kashiba, Misato, Terashima, Masayuki, Sagawa, Tomofumi, Yoshimura, Shinichi, Yamamoto, Yorihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: the Society for Free Radical Research Japan 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370525/
https://www.ncbi.nlm.nih.gov/pubmed/28366985
http://dx.doi.org/10.3164/jcbn.16-32

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370525/
https://www.ncbi.nlm.nih.gov/pubmed/28366985
http://dx.doi.org/10.3164/jcbn.16-32

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